3D Photostimulation
3D photostimulation enables precise, selective control of neural activity using light-sensitive ion channels, combining multicolor photostimulation with high-speed two-photon imaging and sub-millisecond switching.
About 3D Photostimulation
The essence of optogenetics is introducing light-activated recombinant ion channels such as channelrhodopsin (ChR2) or halorhodopsin (NpHR) into excitable cells. Light activation of these molecules leads to an influx of ions which induces turning neurons on or off selectively. Halorhodopsin and channelrhodopsin together enable multicolor optical activation, silencing, and desynchronization of neural activity, creating a powerful neuroengineering toolbox. Photostimulation can be induced using visible or infrared light, while imaging is performed by a femtosecond IR laser. Switching between the stimulation and imaging is done at a sub-millisecond scale. Importantly the detectors are protected during the stimulation by a built-in gating system.
Key features of 3D Photostimulation
3D Photostimulation and Imaging
Full-Field Illumination
Stimulation along ROIs
Simultaneous photoactivation and imaging
Advance your research with 3D Photostimulation
Talk to an application specialist about your research, or book a demo at one of our facilities.