Electrophysiology
Combining two-photon Ca²⁺ imaging with electrophysiology enables simultaneous monitoring of neural activity with high spatial and temporal resolution, linking calcium dynamics to rapid electrical signals.
About Electrophysiology
Two-photon Ca2+ imaging and electrophysiological data acquisition provide powerful tools for the study of neuronal cells and network activity. The simultaneos application of the two methodologies enables the monitoring of the membrane potential fluctuation and their correletion with the intracellular Ca2+ levels. While two-photon Ca2+ imaging technique can capture events in multiple subcellular areas (distinguishable parts of dendrites and spines) at high spatial resolution (less than 1 µm) but low temporal resolution (>100 ms), electrophysiology provides exceptional temporal resolution (<1 ms) for monitoring dynamics with limited single cell resolution.
Key features of Electrophysiology
Dendritic patch-clamp
Processing of electrophysiological data
Advance your research with Electrophysiology
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